biology
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Clinical features •Rare cutaneous lymphoma with a generally good prognosis except for patients who develop a hemophagocytosis syndrome •2F:1M •Wide age range, can affect children & adolescents •Asymptomatic erythematous/violaceus nodules or deep plaques •Limbs & trunk but may be widespread •Variable B-symptoms in up to 50% of patients •Anemia, cytopenia, high ESR & abnormal liver function •Hemophagocytosis syndrome (20% of cases) •Coexistent autoimmune disease…
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Clinical features •Head (scalp), neck, limbs but can occur anywhere •Slowly grown sharply circumscribed flesh colored/erythematous or blue nodule or cystic nodule 0.5-3 cm diameter •Generally symptomatic but can be pruritic or tender •Mostly 3rd– 5th decades (3-93 years) •Slight predominance in females Histological features •Solid or cystic sharply defined nodule in dermis sometimes extending into subcutaneous fat •Eccrine (predominantly poroid & cuticular cells) & apocrine variants (association with a follicle, decapitation secretion & GCDFP-15+ve) •May overlap with poroma…
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•Extremely rare often amelanotic, high-grade variant (based on the majority of documented cases representing metastases. The biological potential of primary tumors with rhabdoid features is uncertain owing to the paucity of reported cases) •Metastases & recurrent disease>>primary tumors •Characterized by pleomorphic tumor cells with large eosinophilic, hyaline globular inclusions and eccentric vesicular nuclei containing prominent nucleoli, mitoses often conspicuous •Inclusions predominantly composed of vimentin intermediate filaments •Immunophenotype is variable with possible loss of expression…
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Clinical features •Presents as a small pigmented papule or nodule on sun-damaged skin •3m:1F •28-92 years (mean 70) •0.2-2.5 cm (mean 0.8) diameter •Head, extremities, trunk in descending order of frequency Rarely recurs Histological features •Well circumscribed nodular or multinodular growth pattern •Admixture of basaloid matrical, supramatricial & eosinophilic shadow cells with dendritic melanocytes. The ghost cell change is distinctive affecting…
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Clinical features •Very rare •M=F •Age range 18-91 •Axilla>>scalp, eyelid, ear, anogenital region, chest, lip & wrist •Slowly growing sometimes ulcerated nodule or plaque •Rarely develops in a nevus sebaceus or complicates a benign precursor apocrine tumor •Often slowly growing and fairly indolent although high grade variants are not uncommon •Metastases to lymph nodes (50%), lung and bone •Recurrence rate 28% •Median survival: 51.5 months •Nodal and distant…
McKee Derm 