epidermolysis-bullosa

Dystrophic epidermolysis bullosa (DEB) develops as a consequence of mutations in COL7A1. This results in defective or absent anchoring fibrils. As a consequence the skin is susceptible to shearing blisters with even minor trauma. Repeated blistering and ulceration complicated by severe scarring results. Squamous cell carcinoma (SCC) is most often encountered on the extremities. Current…