lentigo-maligna

Clinical fetaures •4% of melanoma cases in the USA •Predominantly affects sun damaged skin of the elderly •Malar region, nose, temple, forehead •Less of back of hand •Variably pigmented slowly growing macule with irregular borders & variable pigmentation •Papule or nodule formation indicates invasive tumor •Hypopigmentation is strongly suggestive of regression Histological features & immunohistochemstry •Epidermal atrophy & solar elastosis •Atypical melanocytes located predominantly along the basal layer of the epidermis, singly,…