melanoma
-
Balloon cell nevus represents the benign counterpart of balloon cell melanoma. Clinical features . Most common in first 3 decades . Head & neck > trunk & extremities although any site may be affected including the mucosae . No sex predilection Histological features .Balloon cell change is most often seen in banal melanocytic nevi but…
-
Although desmoplasia may exceptionally be encountered in banal/common and congenital nevi, the overwhelming majority of cases represent sclerosis in Spitz nevi. Desmoplastic blue neves is discussed in a separate blog. Desmoplastic nevus arising on chronic sun-damaged skin has also been described. Clinical features Desmoplastic Spitz nevus presents as a usually small, erythematous papule or nodule…
-
Clinical features •In the older literature also known as juvenile melanoma, spindle & epithelioid cell nevus •First described by Sophie Spitz in 1948 •Approximately 1% of nevi in children •Most often presents in children & adolescents but may be seen the middle aged •Although cases have been documented in the elderly, I would advise extreme…
-
Nevi presenting in the genitalia, inguinal region, umbilicus, axilla and breast may show considerable atypia. They should be readily recognised, often at scanning magnification but may be misdiagnosed as melanoma if the age of the patient and site of the lesion are not taken into account. So-called atypical acral nevus, ear & scalp nevi are…
-
In the older literature this lesion has previously been called epithelioid blue nevus, animal type melanoma, pigment synthesizing melanoma & equine melanoma. Indeed, my cases of so-called animal type melanoma were re-classified as pigmented epithelioid melanocytoma during the preparation of the seminal paper on the topic by Zembowicz & Carney. Clinical features •Most common in…
-
•Extremely rare often amelanotic, high-grade variant (based on the majority of documented cases representing metastases. The biological potential of primary tumors with rhabdoid features is uncertain owing to the paucity of reported cases) •Metastases & recurrent disease>>primary tumors •Characterized by pleomorphic tumor cells with large eosinophilic, hyaline globular inclusions and eccentric vesicular nuclei containing prominent nucleoli, mitoses often conspicuous •Inclusions predominantly composed of vimentin intermediate filaments •Immunophenotype is variable with possible loss of expression…
-
Clinical fetaures •4% of melanoma cases in the USA •Predominantly affects sun damaged skin of the elderly •Malar region, nose, temple, forehead •Less of back of hand •Variably pigmented slowly growing macule with irregular borders & variable pigmentation •Papule or nodule formation indicates invasive tumor •Hypopigmentation is strongly suggestive of regression Histological features & immunohistochemstry •Epidermal atrophy & solar elastosis •Atypical melanocytes located predominantly along the basal layer of the epidermis, singly,…
-
Dysplastic nevi can be sporadic (much more common) or multiple. In patients with dysplastic nevus syndrome (Familial Atypical Multiple Mole Melanoma syndrome) dysplastic nevi may number in hundreds. Patients with this syndrome are at a great risk of developing melanoma (de novo much more often than complicating a dysplastic nevus) Clinical features •Sporadic>>familial •10% of…
-
A rare variant of melanoma which may exists as a pure subtype or represent part of a conventional melanoma where a more typical spindled morphology is present (this second subtype behaves no differently from any other melanoma). Clinical features •Rare sub-type (<4%) •High CSD •Head, neck & upper trunk++, •Scalp alopecia •+/- MIS •Around 50%…
McKee Derm 