nevi

Definition A destinctive melanocytic tumor which may arise sporadically or less often represent a germline mutation in the tumor-suppressor gene BRCA1-associated protein-1 (BAP1). The latter is associated with an increased risk of devloping mesothelioma, uveal melanoma, cutaneous melanoma, Merkel cell carcinoma, basal cell carcinoma, meningioma & renal cell carcinoma Alternative nomenclature •BAP1-inactivated melanocytic tumors (BINT)…