skin-cancer
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Trichoepithelioma is a hamartoma comprising a basaloid/germinative component and a prominent perifolliclular sheath proliferation. It may present as a solitary lesion or as multiple, familial lesions in multiple familial trichoepithelioma (which is probably a variant of Brook-Spiegler syndrome) & Brook-Spiegler syndrome. Clinical features •Solitary trichoepithelioma presents as a flesh-colored papule or nodule (<1.0 cm) most…
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Balloon cell nevus represents the benign counterpart of balloon cell melanoma. Clinical features . Most common in first 3 decades . Head & neck > trunk & extremities although any site may be affected including the mucosae . No sex predilection Histological features .Balloon cell change is most often seen in banal melanocytic nevi but…
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Although desmoplasia may exceptionally be encountered in banal/common and congenital nevi, the overwhelming majority of cases represent sclerosis in Spitz nevi. Desmoplastic blue neves is discussed in a separate blog. Desmoplastic nevus arising on chronic sun-damaged skin has also been described. Clinical features Desmoplastic Spitz nevus presents as a usually small, erythematous papule or nodule…
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Clinical features •In the older literature also known as juvenile melanoma, spindle & epithelioid cell nevus •First described by Sophie Spitz in 1948 •Approximately 1% of nevi in children •Most often presents in children & adolescents but may be seen the middle aged •Although cases have been documented in the elderly, I would advise extreme…
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Nevi presenting in the genitalia, inguinal region, umbilicus, axilla and breast may show considerable atypia. They should be readily recognised, often at scanning magnification but may be misdiagnosed as melanoma if the age of the patient and site of the lesion are not taken into account. So-called atypical acral nevus, ear & scalp nevi are…
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In the older literature this lesion has previously been called epithelioid blue nevus, animal type melanoma, pigment synthesizing melanoma & equine melanoma. Indeed, my cases of so-called animal type melanoma were re-classified as pigmented epithelioid melanocytoma during the preparation of the seminal paper on the topic by Zembowicz & Carney. Clinical features •Most common in…
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Clinical features •Proliferative nodules arise in giant (& occasionally small) congenital nevi •Develop in 2.9-19% of giant congenital nevi •Lesions can be single or multiple & are generally present at birth •Coloration varies from brown to black although deep seated lesions may not be apparent to the naked eye •The natural history is of spontaneous regression •Their importance is that they may be misdiagnosed by the unwary as neonatal melanoma •Congenital & neonatal melanoma is vanishingly…
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Definition A destinctive melanocytic tumor which may arise sporadically or less often represent a germline mutation in the tumor-suppressor gene BRCA1-associated protein-1 (BAP1). The latter is associated with an increased risk of devloping mesothelioma, uveal melanoma, cutaneous melanoma, Merkel cell carcinoma, basal cell carcinoma, meningioma & renal cell carcinoma Alternative nomenclature •BAP1-inactivated melanocytic tumors (BINT)…
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Dysplastic nevi can be sporadic (much more common) or multiple. In patients with dysplastic nevus syndrome (Familial Atypical Multiple Mole Melanoma syndrome) dysplastic nevi may number in hundreds. Patients with this syndrome are at a great risk of developing melanoma (de novo much more often than complicating a dysplastic nevus) Clinical features •Sporadic>>familial •10% of…
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A rare variant of melanoma which may exists as a pure subtype or represent part of a conventional melanoma where a more typical spindled morphology is present (this second subtype behaves no differently from any other melanoma). Clinical features •Rare sub-type (<4%) •High CSD •Head, neck & upper trunk++, •Scalp alopecia •+/- MIS •Around 50%…
McKee Derm 