cancer
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Definition A destinctive melanocytic tumor which may arise sporadically or less often represent a germline mutation in the tumor-suppressor gene BRCA1-associated protein-1 (BAP1). The latter is associated with an increased risk of devloping mesothelioma, uveal melanoma, cutaneous melanoma, Merkel cell carcinoma, basal cell carcinoma, meningioma & renal cell carcinoma Alternative nomenclature •BAP1-inactivated melanocytic tumors (BINT)…
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Dysplastic nevi can be sporadic (much more common) or multiple. In patients with dysplastic nevus syndrome (Familial Atypical Multiple Mole Melanoma syndrome) dysplastic nevi may number in hundreds. Patients with this syndrome are at a great risk of developing melanoma (de novo much more often than complicating a dysplastic nevus) Clinical features •Sporadic>>familial •10% of…
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A rare variant of melanoma which may exists as a pure subtype or represent part of a conventional melanoma where a more typical spindled morphology is present (this second subtype behaves no differently from any other melanoma). Clinical features •Rare sub-type (<4%) •High CSD •Head, neck & upper trunk++, •Scalp alopecia •+/- MIS •Around 50%…
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Two subtypes Clinical features •Usually slowly growing tumors •Predilection for the scalp •M>F •No age predilection & exceptionally, lesions can develop in children •High grade tumor probably related to delay in diagnosis & hence marked tumor thickness •Metastases develop in around 50% of cases to lymph nodes, lung & liver Histological features •Develops within a precursor lesion as one or more nodules of epithelioid or spindled cell melanoma •Or melanoma showing admixed blue nevus-like…
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Clinical features •Very rare variant of melanoma •M=F •Middle aged to elderly (mean age 57 years) •Back> lower & upper extremities> head & neck> choroid •Often ulcerated nodules •Balloon cells may be present in a metastasis & not in the primary tumor (and vice versa) •Poor prognosis is likely related to large tumor size at presentation Histological…
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Definition & clinical features •A melanoma which you diagnosed as nevus and wish that you hadn’t!; a melanoma that closely mimics especially on scanning magnification •The correct diagnosis often comes to light when it recurs or metastasizes •Results from insufficient time being spend on a nevoid lesion •Behaves no differently than any other melanoma •Everyone…
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Clinical features •Exceedingly rare tumor comprising squamous cell carcinoma (in the superficial part) and adenocarcinoma in the deeper reaches. Often misdiagnosed in shave biopsies & sometimes confused with microcystic adnexal carcinoma •Middle aged to elderly patients •Slight predilection for males •Head, neck & extremities on sun-damaged skin •Recurrences common, may spread to lymph nodes or systemically & can rarely cause death…
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Clinical features •Presents as a small pigmented papule or nodule on sun-damaged skin •3m:1F •28-92 years (mean 70) •0.2-2.5 cm (mean 0.8) diameter •Head, extremities, trunk in descending order of frequency Rarely recurs Histological features •Well circumscribed nodular or multinodular growth pattern •Admixture of basaloid matrical, supramatricial & eosinophilic shadow cells with dendritic melanocytes. The ghost cell change is distinctive affecting…
McKee Derm 