Common nevi- basics for beginners

•The late Bernie Ackerman classified acquired melanocytic nevi into Miescher nevus which most commonly occurs on the face and Unna nevus which generally presents on or below the neck

•Miescher nevus is typically dome-shaped

•In Miescher nevus, the nevus is generally dermal, wedge shaped & extends into the reticular dermis

•Unna nevus presents as an exophytic, light to dark brown, polypoid, verrucous or sometimes sessile lesion with a predilection for the neck, trunk & arms

•In Unna nevus, the nevus is predominantly adventitial & therefore is restricted to the papillary dermis & and often includes a perifollicular adventitial element

Type-A cells

Junctional nevus

.Nests are prefernatially located at the tips of the rete ridges (compare with dysplastic where nests are often present on the sides of the rete and overling the dermal papilla)

.Composed of type-A cells- abundant eosinophilic or finely granular, pigmented cytoplasm

.Vesicular nuclei with small nucleoli

Compound nevus

The nevus includes junctional and dermal components (the latter often comprises type-A cells superficially merging wiht type-B nevus cells in the deeper reaches)

.Type-B nevus cells have scant cytoplasm and dense, basophilic cyoplasm

.The nevus shows maturation with depth- nest and cell size get smaller with increasing depth

Dermal nevus

.The nevus is confined to the papillary dermis with or without involvement of the reticular dermis

.Superficially may be composed of type-A nevus cells or just type-B nevus cells. In the deeper reaches, there are type-C spindled cells sometimes showing neurotization and forming Meissner corpuscle-like bodies

. Multinucleate giant cells are sometimes present

.Adipocytes can be present

Junctional nevus
Junctional nevus
Junctional nevus
Compound nevus-type A nevus cells

Type-A nevus cells with mitosis

Compound nevus
Compound nevus
Compound nevus
Compound nevus with junctional activity
Compound nevus
Compound nevus
Dermal nevus
Type-B nevus cells
Types-B & spindled C cells with maturation
Neurotization
Multinuleate giant cells in a dermal nevus
Multinucleate cells in a dermal nevus
Dermal nevus with fatty infiltration
Dermal nevus with myxoid change
Dermal nevus with pseudovascular change
Dermal nevus with psudovascular invasion
Dermal nevus- Masson’s trichrome stain. Fine collagen surrounds and separates individual nevus cells- the opposite is seen in melanoma
Elastophagocytosis is an exceptional finding
Dermal nevus with maturation
Dermal nevus with balloon cell change
Dermal nevus showing loss of pigment with depth
Dermal nevus with mitosis
Dermal nevus with mitosis- type-B cells
Dermal nevus with mitosis- center of the field
Nevus with melanoma- nevus cells are type-B with hyperchromatic, blue nuclei
Nevus with melanoma (upper field)
Nevus with melanoma- the melanoma cells with vesicular nuclei contrast with the type-B nevus cells

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