Clinical features

•Uncommon

•Head & neck with predilection for the cheek but can present at a wide variety of sites where apocrine are normally found

•Dome-shaped, translucent, bluish/purple/black cystic nodule measuring up to 1.0-1.5 cm

•Giant variant

•Occurrence in nevus sebaceus

•Exceptionally described in the parotid gland (Achour et al, 2023)

•M=F

•Middle-aged; occasionally seen in children

•Moll gland cyst (eyelid), may cause ptosis

•Occasionally multiple +/- association with Schöpf-Schulz-Passarge & Golz syndromes

Histological features

•Pseudo-encapsulated unilocular or multilocular

•Outer myoepithelial cells & inner layer of columnar cells with eosinophilic cytoplasm showing decapitation secretion

•DPAS +ve intracytoplasmic granules

•Adenomatous/papillary component (cystadenoma)

•CK7, CK18, GATA3, HMFG, GCDFP-15+ve

•Myoepithelial cells SMA, S100, p63 +ve