Uncategorized
-
Dysplastic nevi can be sporadic (much more common) or multiple. In patients with dysplastic nevus syndrome (Familial Atypical Multiple Mole Melanoma syndrome) dysplastic nevi may number in hundreds. Patients with this syndrome are at a great risk of developing melanoma (de novo much more often than complicating a dysplastic nevus) Clinical features •Sporadic>>familial •10% of…
-
A rare variant of melanoma which may exists as a pure subtype or represent part of a conventional melanoma where a more typical spindled morphology is present (this second subtype behaves no differently from any other melanoma). Clinical features •Rare sub-type (<4%) •High CSD •Head, neck & upper trunk++, •Scalp alopecia •+/- MIS •Around 50%…
-
Two subtypes Clinical features •Usually slowly growing tumors •Predilection for the scalp •M>F •No age predilection & exceptionally, lesions can develop in children •High grade tumor probably related to delay in diagnosis & hence marked tumor thickness •Metastases develop in around 50% of cases to lymph nodes, lung & liver Histological features •Develops within a precursor lesion as one or more nodules of epithelioid or spindled cell melanoma •Or melanoma showing admixed blue nevus-like…
-
A variant of nodular melanoma which shows some/many of the features typically seen in Spitz nevus It can be divided into 3 categories Clinical features While any age may be affected, the majority occur in the 2nd decade with a predilection for females Exceptionally, cases are encountered in children Prognosis depends upon the subtype (see…
-
A very rare subtype of melanoma characterized by slow growth often over many years. I regard atypical lentiginous nevus of the elderly as likely representing the same thing. I would be interested to know others’ views on this matter. Clinical features 2. Generally seen in the middle aged or elderly although younger patients can rarely…
-
•A variant of nevoid melanoma •Predominately in the middle-aged & elderly (mostly 60 years or more) •Predisposition for the trunk & limbs •>6.0 mm diameter •Globular pattern on dermoscopy •Asymmetry & poor circumscription •Variably sized, variably located, expansile, cannon ball-like intra-epidermal nests with thinned surrounding epidermis •Finely granular pigment often evident •Nests lack rete ridge tip preferential location •Bridging sometimes present &…
-
A rare variant of melanoma in which stromal cells produce excess acid mucopolysaccharides inprting a striking myxoid quality. The mucin is Alcian blue & colloidal iron positive, DPAS negative and the melanoma cells stain with typical markeres including S100 & HMB45. It may be seen in primary, recurrent or most often in metastatic lesions. The…
-
An exceedingly rare variant of melanoma. The term includes cases of melanoma that show features of an associated inherited bullous dermatosis such as epidermolysis bullosa or acquired immunobullous intraepidermal or sub epidermal bullous dermatosis such as pemphigus or bullous pemphigoid and cases where the blister develops directly overlying the melanoma in the absence of any…
McKee Derm 