Uncategorized
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Clinical features •Slight predilection for males •1.9 per 100,000 person years •Wide age range (8-91, median 73) •May arise in an eccrine poroma (11%) •Exceptionally complicates nevus sebaceus •Lower limb (44%)> trunk (24%)> head (18%) and upper limb (11%) •Sometimes ulcerated verrucous plaque •Recurrences (17%), nodal metastases (19%), systemic spread (11%), mortality (7-11%) Histological features •Association with UVB and immunosuppression •In situ (malignant hidroacanthoma simplex) •Continuity/origin…
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Clinical features •Exceedingly rare •Documented cases (12 in total)- no metastases or mortality reported •Does this tumor really represent a carcinoma? •F>M •Most often presents on the limbs as a 1-3 cm nodule or cyst Histological features •Generally circumscribed nodules/cysts •Interconnecting epithelial strands giving rise to the cribriform growth pattern •Ductal differentiation •Hyperchromatic nuclei with variable pleomorphism •Mitoses sparse or absent •Focal decapitation secretion and presence of more typical apocrine carcinoma-like…
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Clinical features •Very rare •M=F •Age range 18-91 •Axilla>>scalp, eyelid, ear, anogenital region, chest, lip & wrist •Slowly growing sometimes ulcerated nodule or plaque •Rarely develops in a nevus sebaceus or complicates a benign precursor apocrine tumor •Often slowly growing and fairly indolent although high grade variants are not uncommon •Metastases to lymph nodes (50%), lung and bone •Recurrence rate 28% •Median survival: 51.5 months •Nodal and distant…
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Clinical features •Extremely rare and arises in a benign precursor tumor •Possible association with Brooke-Spiegler syndrome •M=F •Median age 60 years (range 2-92) •Limbs>> face, scalp & chest •Mostly high grade (media survival 10-37%) with metastases to nodes, lung, bone & liver Histological features •Pre-existent spiradenoma •Malignant component shows loss of dual cell population, increased mitotic activity, atypical mitoses & necrosis •Perineural infiltration & LVI may be present •Rarely squamous…
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Clinical features •Extremely rare •13-83 years •Mean age 50.3 years •4F>1M •Sites include axilla (majority of cases), lip, groin, neck,eyelid, thigh and temporal region •Low grade with minimal chance of metastasis (high grade variants have not been documented in the skin) Histological features Unfortunately, I don’t have good images of this tumor but fortunately members of McKee Derm have posted three examples of this…
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Clinical features •Middle aged to elderly •1.5F:1M •Slowly growing nodule •Pain, hyperesthesia & bleeding sometimes evident •Scalp, chest wall & abdomen •Up to 50% recurrence, very rare metastases (lymph nodes, bone, lungs) Histological features •Biphasic tumor (myoepithelial & epithelial) •Cribriform nests, tubules , cords & solid nodules •Presence of myoepithelial cells •Small ducts and pseudocysts…
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Clinical features Histology Histological features Immunohistochemistry Prognosis Differential diagnosis Desmoplastic trichoepithelioma Trichoadenoma Squamoid eccrine ductal carcinoma
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“Dans les champs de L’observation le hasard ne favorise que les esprits préparés”. Louis Pasteur 1854 “Change requires one to start now here or nowhere. Both places require one to pass through the same starting point – today, right now” H. L. Balcomb’s blog Life is a complex series of decisions. Little does one appreciate…
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In the ever-evolving world, the art of forging genuine connections remains timeless. Whether it’s with colleagues, clients, or partners, establishing a genuine rapport paves the way for collaborative success.
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Challenges in business are a given, but it’s our response to them that defines our trajectory. Looking beyond the immediate obstacle, there lies a realm of opportunity and learning.
McKee Derm 