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This is such a large topic. The blog focuses on the clinical appearances and histology. Clinical features •Commonest form of cutaneous T-cell lymphoma although it is very rare with around 1000 new cases diagnosed annually in the USA •2M:1 F •Most common in 4th-6th decades, childhood disease is discussed in a separate blog •In most patients, the…
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Clinical featues •Primary cutaneous disease is very rare (3% of patients with Rosai Dorfman disease) •Benign, self limiting •Skin is commonly involved in patients with nodal disease (10%) •Primary cutaneous disease is more common in middle aged patients & shows a female predominance •Mostly White & Asian populations •Lesions are generally multiple, polymorphic and include papules, nodules or plaques variably flesh colored, pink,…
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Whether this lesions is a distinct entity sui generis is uncertain. Some authors regard it as a variant of actinic lentigo. I do not have rigid views on the matter although in my experience large cell acanthoma does not show the lentiginous epidermal hyperplsia seen in actinic lentigo. Clinical features •Presents as a circumscribed, often…
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Clinical features •Rare tumor which may represent a variant of BCC or a fenestrated trichoblastoma •Predominantly seen in the middle-aged or elderly •F>M •Presents mostly on the lower trunk (lumbosacral region) & thighs, less often head & neck •Flesh colored or pink polypoid, nodule or plaque •Occasionally pigmented •Association with prior radiotherapy •Possible syndromic association- gastrointestinal tumors Histological features •Multifocal origin from epidermis •Anastomosing basaloid,…
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Clinical features •2nd commonest malignant skin tumor after BCC (1:4) •Etiology includes UVB, HPV, ionizing radiation, scarring e.g., burns, syndromic e.g., xeroderma pigmentosum, albinism, Rothmund-Thompson syndrome & epidermolysis bullosa, immunosuppression, PUVA, chronic infections e.g., tuberculosis, arsenic & coal tar derivatives •Type I and II skin •M=F •Generally middle aged or elderly but may arise in at risk children •Sun-exposed skin most often affected- face, neck,…
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Epidermolytic hperkeratosis is a feature of a number of conditions including epidermolytic ichthyosis, annular epidermolytic ichthyosis & epidermolytic epidermal nevus. These are associated with mutations in KRT1 or KRT10. Superficial epidermolytic ichthyosis is associated with a mutation in KRT2. Epidermolytic hyperkeratosis may be encountered as an acquired lesion (epidermolytic acanthoma ) whichmay be associated with…
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Aacntholytic acanthoma •Common, solitary keratotic papule or plaque (0.5-1.5 cm) in the elderly •Predilection for males •Trunk, arm & neck but may arise elsewhere •Histology is Darier-like •If dyskeratosis is marked, the term acantholytic dyskeratotic acanthoma has been applied Acantholytic dermatosis of the genitocrural region •Predilection for young or middle-aged females •0.1-0.5 cm single or multiple papules involving the labia majora +/- erythematous or white plaques •Sometimes with involvement of perineum, thighs & inguinal region •In males, the ano-genital regions…
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This blog prepared by myself and Antonina Kalmykova is based on the review that we wrote for Pathology Outlines. I am indebted to Antonina & her technical staff for the innumerable histology cases that were scanned for me. These cases form the basis for the histology and will not be individually acknowledged unless the photogrpahs…
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Clinical features •Uncommon “tumor” which presents as an erythematous or brown dome-shaped papule/plaque 1-4 cm diameter with puncta that frequently bleed with mild trauma •Peripheral scale •Predilection for the lower leg but has been described at a wide variety of sites •Middle-aged or elderly •M=F •Very rarely, multiple lesions •Polypoid variant •Giant variant •Pigmented variant •Eruptive (Blaschkoid) variant Histological features •Most probably a localized inflammatory lesion rather than a true neoplasm •Parakeratotic…
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Clinical features •Exceedingly rare variant •Elderly patients •M>>F •Sun-damaged skin of head & neck •Often rapidly growing, ulcerated, often large exophytic, nodular tumor . 5-year survival-70% Histological features •Tp53, CDKN2A & PIK3CA mutations variable detected •Biphasic tumor •Possible epithelial to mesenchymal transition •Overexpression of YAP may be at least in part responsible for this phenotype •Admixture of squamous carcinoma & pleomorphic spindled cell, osteoid, chondroid, MFH-like +/-…
McKee Derm 